Androgen Receptor Splice Variants Dimerize to Transactivate Target Genes
نویسندگان
چکیده
منابع مشابه
Androgen Receptor Splice Variants Dimerize to Transactivate Target Genes.
Constitutively active androgen receptor splice variants (AR-V) lacking the ligand-binding domain have been implicated in the pathogenesis of castration-resistant prostate cancer and in mediating resistance to newer drugs that target the androgen axis. AR-V regulates expression of both canonical AR targets and a unique set of cancer-specific targets that are enriched for cell-cycle functions. Ho...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2015
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-15-0381